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OCR: tly to Symptoms and signs vary widely, but e symptoms of hypopituitarism relate m hypogonadism in both sexes, in the Most patients with hypopituitarism, ev ever advanced stage, are well nourished; ho oduce severe prolonged hypopituitarism can f extreme weight loss and an appearance may be malnutrition ('pituitary cachexia') whic a nervosa. clinically indistinguishable from anore ma, or In advanced hypopituitarism collapse, on of even death is possible due to a combina ermia and hypoglycaemia, hypothyroidism, hypot hypotension.